American Society for Microbiology published Dr. Jacobs interview "Tuberculosis Treatment and Mycobacterial Genetics" on the March 15th episode of Meet the Microbiologist, hosted by Julie Wolf.
In February the Proceedings of the National Academy of Sciences published a contribution article from the Jacobs lab describing two deletions encoding an enzyme of the respiratory chains in Mycobacterium tuberculosis profoundly effect the viability and virulence of the mycobacterium. Screening compound libraries against both genes will lead to promising drug candidates to fight tuberculosis.
Read the article here.
Vitamin C potentiates the killing of Mycobacterium tuberculosis by the first-line tuberculosis drugs isoniazid and rifampicin in mice
In a paper recently published in Antimicrobial Agents and Chemotherapy, Dr. Catherine Vilcheze discusses her experiments that demonstrate Vitamin C in combination with first-line TB drugs (isoniazid and rifampicin) will kill an M. tuberculosis infection in mice.
Read the paper here
On January 4th Steve Baragona from Voice of America interviewed Dr. Jacobs about these findings in an article you can read here.
Origins of Combination Therapy for Tuberculosis: Lessons for Future Antimicrobial Development and Application
Earlier this year Dr. Michael Berney, formally of the Jacobs Group, was appointed an Assistant Professor in the Microbiology and Immunology Department at the Albert Einstein College of Medicine. Congratulations!
January 19, 2016 in PNAS: Separable roles for Mycobacterium tuberculosis ESX-3 effectors in iron acquisition and virulence
Describes the ESX-3 type VII secretion system's role in iron acquisition in M. tuberculosis
August 4, 2016 in JCI Insight: HSV-2 ΔgD elicits FcγR-effector antibodies that protect against clinical isolates
Describes the how vaccine vector HSV ΔgD completely protects against highly virulent clinical isolates of HSV-1 and HSV-2
September 26, 2016 in J. Bacteriol: Fluorescent Reporter DS6A Mycobacteriophages Reveal Unique Variations in Infectibility and Phage Production in Mycobacteria
Describes the DS6A reporter phage that uniquely plaques to M. tuberculosis. This is the PhD Thesis paper for Dr. Oren Meyer!
October 25, 2016 in mBio: Dual-Reporter Mycobacteriophages (Φ2DRMs) Reveal Preexisting Mycobacterium tuberculosis Persistent Cells in Human Sputum
Describes the development of dual-reporter mycobacteriophages that cause a culture of M. tuberculosis to glow green inititally and glow red when entering a persister state.
The Complete Genome Sequence of the Emerging Pathogen Mycobacterium haemophilum an it's ties to Leprosy